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The role of dalbavancin in skin and soft tissue infections.
- Source :
-
Current opinion in infectious diseases [Curr Opin Infect Dis] 2018 Apr; Vol. 31 (2), pp. 141-147. - Publication Year :
- 2018
-
Abstract
- Purpose of Review: The increase of skin and soft tissue infections (SSTIs) represents a major concern both in community and in the hospital setting. Staphylococcus aureus is the most frequently isolated pathogen, and the rise in infections due to methicillin-resistant Staphylococcus aureus (MRSA) has been associated with inadequate antibiotic treatment and increased morbidity.<br />Recent Findings: A number of new antimicrobials with activity against drug-resistant Gram-positive pathogens, including MRSA, have been recently approved for the treatment of SSTIs. New lipoglycopeptides, in particular dalbavancin, are long-acting antibiotics with potential for infrequent administration, offering the possibility for outpatient treatment and early hospital discharge.<br />Summary: Dalbavancin is a new lipoglycopeptide showing high activity against Gram-positive bacteria, including drug-resistant strains. Dalbavancin presents a distinctive pharmacokinetic profile with a terminal prolonged half-life of approximately 14 days. This characteristic allows once-weekly dosing interval, avoiding the need for daily dosing and offering an advantage over other compounds for potential use in the outpatient setting or to promote early hospital discharge. Dalbavancin has a favorable adverse effect profile and appears to be a promising new alternative for treatment of SSTIs. We have reviewed the pharmacokinetic properties of dalbavancin and the clinical evidence for its use in complicated SSTIs and other potential applications.
- Subjects :
- Anti-Bacterial Agents adverse effects
Anti-Bacterial Agents pharmacokinetics
Drug-Related Side Effects and Adverse Reactions epidemiology
Drug-Related Side Effects and Adverse Reactions pathology
Humans
Teicoplanin adverse effects
Teicoplanin pharmacokinetics
Teicoplanin therapeutic use
Treatment Outcome
Anti-Bacterial Agents therapeutic use
Gram-Positive Bacterial Infections drug therapy
Skin Diseases, Infectious drug therapy
Soft Tissue Infections drug therapy
Teicoplanin analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1473-6527
- Volume :
- 31
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current opinion in infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 29298166
- Full Text :
- https://doi.org/10.1097/QCO.0000000000000430