Upregulation of NETO2 gene in colorectal cancer.

Authors :: Fedorova MS
Snezhkina AV
Pudova EA
Abramov IS
Lipatova AV
Kharitonov SL
Sadritdinova AF
Nyushko KM
Klimina KM
Belyakov MM
Slavnova EN
Melnikova NV
Chernichenko MA
Sidorov DV
Kiseleva MV
Kaprin AD
Alekseev BY
Dmitriev AA
Kudryavtseva AV
Source :: BMC genetics [BMC Genet] 2017 Dec 28; Vol. 18 (Suppl 1), pp. 117. Date of Electronic Publication: 2017 Dec 28.
Publication Year :: 2017
Abstract: Background: Neuropilin and tolloid-like 2 (NETO2) is a single-pass transmembrane protein that has been shown primarily implicated in neuron-specific processes. Upregulation of NETO2 gene was also detected in several cancer types. In colorectal cancer (CRC), it was associated with tumor progression, invasion, and metastasis, and seems to be involved in epithelial-mesenchymal transition (EMT). However, the mechanism of NETO2 action is still poorly understood.<br />Results: We have revealed significant increase in the expression of NETO2 gene and deregulation of eight EMT-related genes in CRC. Four of them were upregulated (TWIST1, SNAIL1, LEF1, and FOXA2); the mRNA levels of other genes (FOXA1, BMP2, BMP5, and SMAD7) were decreased. Expression of NETO2 gene was weakly correlated with that of genes involved in the EMT process.<br />Conclusions: We found considerable NETO2 upregulation, but no significant correlation between the expression of NETO2 and EMT-related genes in CRC. Thus, NETO2 may be involved in CRC progression, but is not directly associated with EMT.