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Lymphadenopathy driven by TCR-V γ 8V δ 1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome.
- Source :
-
Blood advances [Blood Adv] 2017 Jun 22; Vol. 1 (15), pp. 1101-1106. Date of Electronic Publication: 2017 Jun 22 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- FAS-dependent apoptosis in V <subscript>δ</subscript> 1 T cells makes the latter possible culprits for the lymphadenopathy observed in patients with FAS mutations.Rapamycin and methylprednisolone resistance should prompt clinicians to look for V <subscript>δ</subscript> 1 T cell proliferation in ALPS-FAS patients.<br />Competing Interests: Conflict-of-interest disclosure: The authors declare no competing financial interests.
Details
- Language :
- English
- ISSN :
- 2473-9529
- Volume :
- 1
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Blood advances
- Publication Type :
- Academic Journal
- Accession number :
- 29296752
- Full Text :
- https://doi.org/10.1182/bloodadvances.2017006411