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Innovative and New Approaches to Laboratory Diagnosis of Zika and Dengue: A Meeting Report.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2018 Mar 13; Vol. 217 (7), pp. 1060-1068. - Publication Year :
- 2018
-
Abstract
- Epidemics of dengue, Zika, and other arboviral diseases are increasing in frequency and severity. Current efforts to rapidly identify and manage these epidemics are limited by the short diagnostic window in acute infection, the extensive serologic cross-reactivity among flaviviruses, and the lack of point-of-care diagnostic tools to detect these viral species in primary care settings. The Partnership for Dengue Control organized a workshop to review the current landscape of Flavivirus diagnostic tools, identified current gaps, and developed strategies to accelerate the adoption of promising novel technologies into national programs. The rate-limiting step to bringing new diagnostic tools to the market is access to reference materials and well-characterized clinical samples to facilitate performance evaluation. We suggest the creation of an international laboratory-response consortium for flaviviruses with a decentralized biobank of well-characterized samples to facilitate assay validation. Access to proficiency panels are needed to ensure quality control, in additional to in-country capacity building.
- Subjects :
- Antibodies, Viral immunology
Consumer Product Safety
Dengue history
Dengue virology
Dengue Virus genetics
Dengue Virus immunology
Dengue Virus isolation & purification
Enzyme-Linked Immunosorbent Assay history
Enzyme-Linked Immunosorbent Assay methods
Enzyme-Linked Immunosorbent Assay trends
History, 20th Century
History, 21st Century
Humans
Population Surveillance
Reverse Transcriptase Polymerase Chain Reaction history
Reverse Transcriptase Polymerase Chain Reaction methods
Reverse Transcriptase Polymerase Chain Reaction trends
Sensitivity and Specificity
Zika Virus genetics
Zika Virus immunology
Zika Virus isolation & purification
Zika Virus Infection history
Zika Virus Infection virology
Antibodies, Viral blood
Dengue diagnosis
Zika Virus Infection diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 217
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Report
- Accession number :
- 29294035
- Full Text :
- https://doi.org/10.1093/infdis/jix678