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Shared mechanisms regulate spatiotemporal RhoA-dependent actomyosin contractility during adhesion and cell division.
- Source :
-
Small GTPases [Small GTPases] 2020 Mar; Vol. 11 (2), pp. 113-121. Date of Electronic Publication: 2017 Dec 31. - Publication Year :
- 2020
-
Abstract
- Local modulation of the actin cytoskeleton is essential for the initiation and maintenance of strong homotypic adhesive interfaces between neighboring cells. The epithelial adherens junction (AJ) fulfils a central role in this process by mediating E-cadherin interactions and functioning as a signaling scaffold to control the activity of the small GTPase RhoA and subsequent actomyosin contractility. Interestingly, a number of regulatory proteins that modulate RhoA activity at the AJ also control RhoA during cytokinesis, an actomyosin-dependent process that divides the cytoplasm to generate two daughter cells at the final stages of mitosis. Recent insights have revealed that the central player in AJ stability, p120-catenin (p120), interacts with and modulates essential regulators of actomyosin contraction during cytokinesis. In cancer, loss of this modulation is a common event during tumor progression that can induce chromosomal instability and tumor progression.In this review, we will highlight the functional differences and similarities of the different RhoA-associated factors that have been linked to both the regulation of cell-cell adhesion and cytokinesis.
Details
- Language :
- English
- ISSN :
- 2154-1256
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Small GTPases
- Publication Type :
- Academic Journal
- Accession number :
- 29291271
- Full Text :
- https://doi.org/10.1080/21541248.2017.1366966