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Differences in incidence and survival of oral cavity and pharyngeal cancers between Germany and the United States depend on the HPV-association of the cancer site.
- Source :
-
Oral oncology [Oral Oncol] 2018 Jan; Vol. 76, pp. 8-15. Date of Electronic Publication: 2017 Nov 21. - Publication Year :
- 2018
-
Abstract
- Introduction: The epidemiology of squamous cell oral cavity and pharyngeal cancers (OCPC) has changed rapidly during the last years, possibly due to an increase of human papilloma virus (HPV) positive tumors and successes in tobacco prevention. Here, we compare incidence and survival of OCPC by HPV-relation of the site in Germany and the United States (US).<br />Materials and Methods: Age-standardized and age-specific incidence and 5-year relative survival was estimated using data from population-based cancer registries in Germany and the US Surveillance Epidemiology and End Results (SEER) 13 database. Incidence was estimated for each year between 1999 and 2013. Relative survival for 2002-2005, 2006-2009, and 2010-2013 was estimated using period analysis.<br />Results: The datasets included 52,787 and 48,861 cases with OCPC diagnosis between 1997 and 2013 in Germany and the US. Incidence was much higher in Germany compared to the US for HPV-unrelated OCPC and more recently also for HPV-related OCPC in women. Five-year relative survival differences between Germany and the US were small for HPV-unrelated OCPC. For HPV-related OCPC, men had higher survival in the US (62.1%) than in Germany (45.4%) in 2010-2013. These differences increased over time and were largest in younger patients and stage IV disease without metastasis. In contrast, women had comparable survival for HPV-related OCPC in both countries.<br />Conclusions: Strong survival differences between Germany and the US were observed for HPV-related OCPC in men, which might be explained by differences in HPV-attributable proportions. Close monitoring of the epidemiology of OCPC in each country is needed.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Female
Germany epidemiology
Humans
Incidence
Male
Middle Aged
Mouth Neoplasms complications
Mouth Neoplasms virology
Pharyngeal Neoplasms complications
Pharyngeal Neoplasms virology
Survival Analysis
United States epidemiology
Young Adult
Mouth Neoplasms epidemiology
Mouth Neoplasms physiopathology
Papillomavirus Infections complications
Pharyngeal Neoplasms epidemiology
Pharyngeal Neoplasms physiopathology
Tumor Virus Infections complications
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0593
- Volume :
- 76
- Database :
- MEDLINE
- Journal :
- Oral oncology
- Publication Type :
- Academic Journal
- Accession number :
- 29290288
- Full Text :
- https://doi.org/10.1016/j.oraloncology.2017.11.015