Back to Search Start Over

The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.

Authors :
Farrugia BL
Lord MS
Melrose J
Whitelock JM
Source :
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2018 Apr; Vol. 66 (4), pp. 321-336. Date of Electronic Publication: 2018 Jan 01.
Publication Year :
2018

Abstract

Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation. These events are modulated by chemokines, integrins, and selectins and the interaction of these molecules with glycosaminoglycans, predominantly heparan sulfate (HS). The development of HS/heparin mimetics that interfere or inhibit the interactions that occur between glycosaminoglycans and modulators of inflammation holds great potential for use as anti-inflammatory therapeutics. This review will detail the role of HS in the events that occur during inflammation, their interaction and modulation of inflammatory mediators, and the current advances in the development of HS/heparin mimetics as anti-inflammatory biotherapeutics.

Details

Language :
English
ISSN :
1551-5044
Volume :
66
Issue :
4
Database :
MEDLINE
Journal :
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Publication Type :
Academic Journal
Accession number :
29290153
Full Text :
https://doi.org/10.1369/0022155417740881