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The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.
- Source :
-
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2018 Apr; Vol. 66 (4), pp. 321-336. Date of Electronic Publication: 2018 Jan 01. - Publication Year :
- 2018
-
Abstract
- Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation. These events are modulated by chemokines, integrins, and selectins and the interaction of these molecules with glycosaminoglycans, predominantly heparan sulfate (HS). The development of HS/heparin mimetics that interfere or inhibit the interactions that occur between glycosaminoglycans and modulators of inflammation holds great potential for use as anti-inflammatory therapeutics. This review will detail the role of HS in the events that occur during inflammation, their interaction and modulation of inflammatory mediators, and the current advances in the development of HS/heparin mimetics as anti-inflammatory biotherapeutics.
- Subjects :
- Animals
Anti-Inflammatory Agents chemistry
Biomimetics methods
Chemokines immunology
Glucuronidase antagonists & inhibitors
Glucuronidase immunology
Heparitin Sulfate chemistry
Humans
Inflammation drug therapy
Anti-Inflammatory Agents immunology
Anti-Inflammatory Agents pharmacology
Drug Discovery methods
Heparitin Sulfate immunology
Heparitin Sulfate pharmacology
Immunity, Innate drug effects
Inflammation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1551-5044
- Volume :
- 66
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
- Publication Type :
- Academic Journal
- Accession number :
- 29290153
- Full Text :
- https://doi.org/10.1369/0022155417740881