New 2-arylbenzofurans from the root bark of Artocarpus gomezianus and their α-glucosidase inhibitory activity.

Two new 2-arylbenzofurans, namely 13- O -methyllakoochin B ( 1 ) and artogomezianin ( 2 ), were isolated from the root bark of Artocarpus gomezianus , along with six known compounds ( 3 - 8 ). The structures of new compounds were determined by spectroscopic and chemical methods. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Artogomezianin ( 2 ) and lakoochin A ( 3 ) exhibited strong α-glucosidase inhibitory activity with IC ₅₀ values of 18.25 and 26.19 µM, respectively, as compared with the positive control acarbose.