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Evaluation of the suitability of a Sprague Dawley rat model to assess intravenous iron preparations.
- Source :
-
Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2018 May - Jun; Vol. 91, pp. 7-17. Date of Electronic Publication: 2017 Dec 24. - Publication Year :
- 2018
-
Abstract
- The aim of the study was to examine the reproducibility of a rat model to assess the preclinical similarity in safety profiles and tissue accumulation of iron products. Accordingly, the effect of several doses of intravenously administered Venofer® and of Ferrlecit® on blood parameters, and on kidney and particularly liver toxicity were examined in non-anemic Sprague Dawley rats. The different analysis showed neither a clear treatment nor a dose effect after multiple injections. The parameters measured in this rat strain showed some iron induced adverse effects, but these could not be correlated to treatment specific differences. The findings presented in this paper indicate the difficulty to define a useful preclinical model to evaluate iron-based nano-colloidal preparations.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Colloids administration & dosage
Colloids toxicity
Ferric Compounds administration & dosage
Ferric Compounds toxicity
Ferric Oxide, Saccharated
Glucaric Acid administration & dosage
Glucaric Acid toxicity
Hematinics administration & dosage
Infusions, Intravenous
Injections, Intravenous
Male
Nanoparticles administration & dosage
Nanoparticles toxicity
Rats, Sprague-Dawley
Reproducibility of Results
Hematinics toxicity
Kidney drug effects
Liver drug effects
Models, Animal
Rats
Subjects
Details
- Language :
- English
- ISSN :
- 1873-488X
- Volume :
- 91
- Database :
- MEDLINE
- Journal :
- Journal of pharmacological and toxicological methods
- Publication Type :
- Academic Journal
- Accession number :
- 29278742
- Full Text :
- https://doi.org/10.1016/j.vascn.2017.12.001