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Antimonial susceptibility and in vivo behaviour of Leishmania major isolates collected in Algeria before and after treatment.
- Source :
-
Acta tropica [Acta Trop] 2018 Apr; Vol. 180, pp. 7-11. Date of Electronic Publication: 2017 Dec 24. - Publication Year :
- 2018
-
Abstract
- The repercussions of cutaneous leishmaniasis therapy on the behaviour and drug susceptibility of Leishmania major parasites is poorly documented. This study explored the link between antimonial susceptibility and in vivo behaviour in Leishmania major isolates collected before and after treatment in Algeria. This study was performed on 3 isolates collected from patients prior to treatment and paired with 3 isolates collected from the same patient after treatment failure. Their in vitro susceptibility towards trivalent (SbIII) and pentavalent (SbV) antimony were ascertained, and their in vivo behaviour was evaluated by determining their capacity to disseminate, proliferate and induce lesions in mice. No relationship was observed between in vitro antimony resistance and parasite fitness in the murine model.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Algeria
Animals
Humans
Leishmania major isolation & purification
Leishmaniasis, Cutaneous parasitology
Male
Meglumine Antimoniate
Mice
Middle Aged
Treatment Failure
Young Adult
Antiprotozoal Agents pharmacology
Drug Resistance, Microbial drug effects
Leishmania major drug effects
Leishmaniasis, Cutaneous drug therapy
Meglumine pharmacology
Organometallic Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6254
- Volume :
- 180
- Database :
- MEDLINE
- Journal :
- Acta tropica
- Publication Type :
- Academic Journal
- Accession number :
- 29278674
- Full Text :
- https://doi.org/10.1016/j.actatropica.2017.12.020