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EZH2 Overexpression as a Useful Prognostic Marker for Aggressive Behaviour in Thyroid Cancer.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2018 Jan-Feb; Vol. 32 (1), pp. 25-31. - Publication Year :
- 2018
-
Abstract
- Background/aim: Enhancer of zeste homolog 2 (EZH2) is a member of the polycomb group of genes, which are key factors in the regulation of cell proliferation and differentiation. EZH2 is overexpressed in many malignancies. We analyzed EZH2 protein expression levels in different histological subtypes of thyroid cancer to examine its utility as a prognostic factor.<br />Materials and Methods: We examined EZH2 protein expression by immunohistochemistry in tissue samples from 67 cases of poorly differentiated (PDTC) and 48 cases of anaplastic thyroid carcinoma (ATC), and in samples of adjacent normal and differentiated thyroid carcinoma (DTC). We examined differences in expression of EZH2 among various histological types of thyroid cancer, and the relationship between EZH2 expression and patient outcome.<br />Results: EZH2 protein was expressed in PDTC and ATC, but not in normal thyroid gland or DTC. EZH-positivity increased in the order of DTC, PDTC, and ATC (p<0.01). Higher EZH2 expression correlated with poorer survival in PDTC (p=0.004), and a similar but non-significant trend was observed in ATC (p=0.166). Multivariate analysis identified EZH2 as an independent prognostic factor similar to metastatic status in the Japanese Society of Thyroid Surgery (JSTS) classification of PDTC.<br />Conclusion: EZH2 overexpression is associated with malignant potential in thyroid cancer, and may thus be a useful prognostic marker of aggressive thyroid cancer.<br /> (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
Prognosis
Retrospective Studies
Thyroid Carcinoma, Anaplastic pathology
Thyroid Neoplasms pathology
Young Adult
Biomarkers, Tumor biosynthesis
Enhancer of Zeste Homolog 2 Protein biosynthesis
Thyroid Carcinoma, Anaplastic metabolism
Thyroid Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7549
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 29275295
- Full Text :
- https://doi.org/10.21873/invivo.11200