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Recent advances in the neurobiology and neuropharmacology of Alzheimer's disease.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2018 Feb; Vol. 98, pp. 297-307. Date of Electronic Publication: 2017 Dec 27. - Publication Year :
- 2018
-
Abstract
- Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by progressive deterioration of cognitive functions. The pathological hallmarks are extracellular deposits of amyloid plaques and intracellular neurofibrillary tangles of tau protein. The cognitive deficits seen are thought to be due to synaptic dysfunction and neurochemical deficiencies. Various neurochemical abnormalities have been observed during progressive ageing, and are linked to cognitive abnormalities as seen with the sporadic form of AD. Acetylcholinesterase inhibitors are one of the major therapeutic strategies used for the treatment of AD. During the last decade, various new therapeutic strategies have shown beneficial effects in preclinical studies and under clinical development for the treatment of AD. The present review is aimed at discussing the neurobiology of AD and association of neurochemical abnormalities associated with cognitive deterioration and new therapeutic strategies for the treatment of AD.<br /> (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Amyloid beta-Peptides antagonists & inhibitors
Amyloid beta-Peptides metabolism
Animals
Antioxidants administration & dosage
Hormone Replacement Therapy trends
Humans
Oxidative Stress drug effects
Oxidative Stress physiology
tau Proteins antagonists & inhibitors
tau Proteins metabolism
Alzheimer Disease drug therapy
Alzheimer Disease metabolism
Neurobiology trends
Neuropharmacology trends
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 98
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 29274586
- Full Text :
- https://doi.org/10.1016/j.biopha.2017.12.053