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Long-term survival after complete resection of non-small-cell lung cancer in patients with interstitial lung disease.
- Source :
-
Interactive cardiovascular and thoracic surgery [Interact Cardiovasc Thorac Surg] 2018 Apr 01; Vol. 26 (4), pp. 638-643. - Publication Year :
- 2018
-
Abstract
- Objectives: Patients with lung cancer and interstitial lung disease (ILD), usual interstitial pneumonia in particular, are known to have a poor outcome. The aim of this study was to evaluate the prognostic impact of ILD in patients with non-small-cell lung cancer.<br />Methods: A total of 2054 consecutive patients underwent complete resection of Stage IA-IIIA non-small-cell lung cancer in our institution between January 2002 and March 2013. The presence of ILD was diagnosed and categorized based on high-resolution computed tomography images. Multivariate analysis was performed to identify the prognostic factors.<br />Results: There were 106 (5%) patients with ILD. There were significantly more patients who developed severe complications (P < 0.01) in the ILD group, with 4 (4%) patients developing acute exacerbation. Although the difference in postoperative mortality rate was marginal between the groups (P = 0.07), the 5-year overall survival and cancer-specific survival rates of the ILD patients were significantly worse than those of the non-ILD group (overall survival: 40.4% vs 72.0%, P < 0.01; cancer-specific survival 55.4% vs 78.6%, P < 0.01). The results of multivariate analysis showed that coexistence of ILD (hazard ratio 1.45; P = 0.01) was an independent, unfavourable prognostic factor.<br />Conclusions: The presence of ILD led to a much poorer survival after complete resection of non-small-cell lung cancer.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung complications
Carcinoma, Non-Small-Cell Lung surgery
Female
Follow-Up Studies
Humans
Japan epidemiology
Lung Diseases, Interstitial mortality
Lung Diseases, Interstitial surgery
Lung Neoplasms complications
Lung Neoplasms surgery
Male
Middle Aged
Prognosis
Survival Rate trends
Time Factors
Young Adult
Carcinoma, Non-Small-Cell Lung mortality
Lung Diseases, Interstitial complications
Lung Neoplasms mortality
Pneumonectomy
Subjects
Details
- Language :
- English
- ISSN :
- 1569-9285
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Interactive cardiovascular and thoracic surgery
- Publication Type :
- Academic Journal
- Accession number :
- 29272403
- Full Text :
- https://doi.org/10.1093/icvts/ivx400