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Shared cancer neoantigens: Making private matters public.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2018 Jan 02; Vol. 215 (1), pp. 5-7. Date of Electronic Publication: 2017 Dec 21. - Publication Year :
- 2018
-
Abstract
- In this issue of JEM, Chheda et al. (https://doi.org/10.1084/jem.20171046) report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, thereby creating a "public" neoantigen.<br /> (© 2018 Klebanoff and Wolchok.)
- Subjects :
- Cell- and Tissue-Based Therapy
Epitopes, T-Lymphocyte
Glioma
Humans
Histones
Mutation
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 215
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 29269561
- Full Text :
- https://doi.org/10.1084/jem.20172188