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Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type.
- Source :
-
Journal of neural transmission [J Neural Transm] 1989; Vol. 75 (3), pp. 227-32. - Publication Year :
- 1989
-
Abstract
- A massive cerebral release of amino acids and ammonia was found in early-onset dementia of Alzheimer type. Aspartate and glycine were liberated in high concentrations, whereas glutamate remained rather unchanged. This excess cerebral protein catabolism is due to a 44% reduction in cerebral glucose metabolism. Whereas glutamate and other glucoplastic amino acids may substitute glucose, elevated aspartate may contribute to neuronal damage. The results are discussed with respect to a possible neuronal insulin/insulin receptor deficiency.
Details
- Language :
- English
- Volume :
- 75
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of neural transmission
- Publication Type :
- Academic Journal
- Accession number :
- 2926384
- Full Text :
- https://doi.org/10.1007/BF01258634