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Estimated Glomerular Filtration Rate, Proteinuria, and Risk of Cardiovascular Diseases and All-cause Mortality in Diabetic Population: a Community-based Cohort Study.
- Source :
-
Scientific reports [Sci Rep] 2017 Dec 20; Vol. 7 (1), pp. 17948. Date of Electronic Publication: 2017 Dec 20. - Publication Year :
- 2017
-
Abstract
- Data about associations between estimated glomerular filtration rate (eGFR) and proteinuria with cardiovascular diseases (CVDs) and all-cause mortality among diabetic population is less described. We aimed to describe these associations in Chinese diabetic population, and investigate the difference between sexes. The study was based on 8,301 diabetic participants in the Kailuan study, who was free of CVDs at baseline. We used Cox proportional hazard models to examine the associations of eGFR and proteinuria with CVDs and all-cause mortality. A stratified analysis by gender was performed. During a median follow-up of 8.05 years, 917 deaths and 813 incident CVDs occurred. Adjusted for all potential confounders, eGFR was associated with all-cause mortality, but not associated with incidence of CVDs. Compared to those with eGFR ≥ 90 ml/min/1.73 m <superscript>2</superscript> , Participants with eGFR <45 ml/min/1.73 m <superscript>2</superscript> had 1.50 fold higher risk of all-cause mortality. Adjusted for all potential confounders, proteinuria was associated with risk of both CVDs and all-cause mortality. Additionally, the risk of all-cause mortality by proteinuria was greater in women than that in men. Both lower eGFR and proteinuria are independent risk factors for all-cause mortality in the Chinese diabetic population. Proteinuria conferred excessive risk for CVDs, and especially in women.
- Subjects :
- Cardiovascular Diseases epidemiology
Cardiovascular Diseases mortality
China epidemiology
Cohort Studies
Diabetes Complications epidemiology
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Mortality
Proteinuria epidemiology
Proteinuria mortality
Risk Factors
Sex Factors
Cardiovascular Diseases etiology
Diabetes Complications mortality
Glomerular Filtration Rate
Proteinuria etiology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29263432
- Full Text :
- https://doi.org/10.1038/s41598-017-17965-z