Back to Search Start Over

Joint Analysis of Strain and Parent-of-Origin Effects for Recombinant Inbred Intercrosses Generated from Multiparent Populations with the Collaborative Cross as an Example.

Authors :
Liu Y
Xiong S
Sun W
Zou F
Source :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2018 Feb 02; Vol. 8 (2), pp. 599-605. Date of Electronic Publication: 2018 Feb 02.
Publication Year :
2018

Abstract

Multiparent populations (MPP) have become popular resources for complex trait mapping because of their wider allelic diversity and larger population size compared with traditional two-way recombinant inbred (RI) strains. In mice, the collaborative cross (CC) is one of the most popular MPP and is derived from eight genetically diverse inbred founder strains. The strategy of generating RI intercrosses (RIX) from MPP in general and from the CC in particular can produce a large number of completely reproducible heterozygote genomes that better represent the (outbred) human population. Since both maternal and paternal haplotypes of each RIX are readily available, RIX is a powerful resource for studying both standing genetic and epigenetic variations of complex traits, in particular, the parent-of-origin (PoO) effects, which are important contributors to many complex traits. Furthermore, most complex traits are affected by >1 genes, where multiple quantitative trait locus mapping could be more advantageous. In this paper, for MPP-RIX data but taking CC-RIX as a working example, we propose a general Bayesian variable selection procedure to simultaneously search for multiple genes with founder allelic effects and PoO effects. The proposed model respects the complex relationship among RIX samples, and the performance of the proposed method is examined by extensive simulations.<br /> (Copyright © 2018 Liu et al.)

Details

Language :
English
ISSN :
2160-1836
Volume :
8
Issue :
2
Database :
MEDLINE
Journal :
G3 (Bethesda, Md.)
Publication Type :
Academic Journal
Accession number :
29255115
Full Text :
https://doi.org/10.1534/g3.117.300483