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Programmed Death-Ligand 1 Expression and EGFR Mutations in Multifocal Lung Cancer.
- Source :
-
The Annals of thoracic surgery [Ann Thorac Surg] 2018 Feb; Vol. 105 (2), pp. 448-454. Date of Electronic Publication: 2017 Dec 15. - Publication Year :
- 2018
-
Abstract
- Background: Little is known about the programmed death-ligand 1 (PD-L1) expression in multifocal lung cancer, such as the expression in multiple primary lung cancer and pulmonary metastasis. In this translational study, we investigated PD-L1 expression and its relationship with the epidermal growth factor receptor (EGFR) mutation status in resected multifocal lung cancer.<br />Methods: The PD-L1 expression in 152 samples of multifocal lung cancer from 59 patients was evaluated by an immunohistochemical analysis.<br />Results: Among the 152 lung cancer lesions of 59 patients, PD-L1 expression was observed in 29 lesions (19.1%) of 20 patients (33.9%). Among 43 patients with 112 multiple primary lung cancer lesions, 15 lesions (13.4%) of 13 patients (30.2%) were PD-L1 positive; and among 16 patients with 40 pulmonary metastatic lesions, 14 lesions (35.0%) of 7 patients (43.8%) were PD-L1-positive. Among 43 patients with multiple primary lung cancer, there was disagreement of PD-L1 expression in 12 patients (27.9%, κ = 0.104). On the contrary, among 16 patients with pulmonary metastasis, disagreement of PD-L1 expression was observed only in 1 patient (6.3%, κ = 0.871). In pulmonary metastatic lesions, the frequency of PD-L1 positivity among lesions with wild-type EGFR was significantly higher than among lesions with mutated EGFR (66.7% versus 0%: p < 0.001).<br />Conclusions: This study provides important evidence of higher levels of agreement of PD-L1 expression in pulmonary metastasis compared with in multiple primary lung cancer, and high positivity of PD-L1 expression in pulmonary metastatic lesions with wild-type EGFR in an Asian population.<br /> (Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
B7-H1 Antigen biosynthesis
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
DNA Mutational Analysis
ErbB Receptors metabolism
Female
Humans
Immunohistochemistry
Lung Neoplasms diagnosis
Lung Neoplasms metabolism
Male
Middle Aged
Polymerase Chain Reaction
B7-H1 Antigen genetics
DNA, Neoplasm genetics
ErbB Receptors genetics
Gene Expression Regulation, Neoplastic
Lung Neoplasms genetics
Mutation
Neoplasm Staging
Subjects
Details
- Language :
- English
- ISSN :
- 1552-6259
- Volume :
- 105
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Annals of thoracic surgery
- Publication Type :
- Academic Journal
- Accession number :
- 29254651
- Full Text :
- https://doi.org/10.1016/j.athoracsur.2017.09.025