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Coagulation in hindbrain membrane meningioma patients treated with different injections using acute hypervolemic hemodilution.
- Source :
-
Journal of biological regulators and homeostatic agents [J Biol Regul Homeost Agents] 2017 Oct-Dec; Vol. 31 (4), pp. 991-996. - Publication Year :
- 2017
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Abstract
- The aim of this study was to analyze the changes in coagulation in meningioma patients treated with different injections using the method of acute hypervolemic hemodilution (AHH). One hundred fifty hindbrain membrane meningioma patients were randomly divided into 5 groups, 30 per group. The first group were injected 40ml/time with Danhong after anesthesia induction; the second group were injected with 40ml~60ml/time Kangai and combined with interventional chemotherapy and embolization procedure; the third group of AHH were injected with polygeline 15ml/kg; the fourth group were injected with hydroxyethyl starch (130/0.4) sodium chloride in doses of 15ml/kg; the control group underwent basic treatment for lowering blood pressure and lowering blood fat. The changes of coagulation index were recorded before and after surgery and before and after the injection of different medications. Compared to the control group, for the first group of AHH, after being treated for 10 days and 30 days, the concentrations of bone specific alkaline phosphatase (BALP), bone Gla protein (BGP) and pro-collagen carboxy-terminal propeptide (PICP) were higher than that of the control group, the levels of endotoxin (ET) and C-reactive protein (CRP) were decreased compared to the control group (p less than 0.05); for the second group of AHH, after being treated for 10 days, the index of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fg) were not significantly changed, but the related level of vascular endothelial growth factor (VEGF) significantly decreased (p less than 0.05). Comparing the coagulation function index after surgery in the third and fourth groups, there were no significant changes in mean arterial pressure (MAP) level, heart rate (HR) value presented a low decrease, central venous pressure (CVP) level increased and the level of interleukin IL-6 showed a steady state after increasing. Analyzing the levels of interleukin IL-8 and tumor necrosis factor-α (TNF-α) after surgery, it was seen that in the third group they increased and in the fourth group they decreased (p less than 0.05). Danhong injection improved the coagulation function and microcirculation of patients, Kangai injection and interventional chemotherapy and embolization restrained the appearance of tumor angiogenesis, AHH operation with polygeline injection and hydroxyethyl starch (130/0.4) sodium chloride kept blood flow in normal parameters.
- Subjects :
- Adult
Alkaline Phosphatase genetics
Alkaline Phosphatase metabolism
Arterial Pressure drug effects
Arterial Pressure physiology
Biomarkers metabolism
Blood Viscosity drug effects
C-Reactive Protein genetics
C-Reactive Protein metabolism
Embolization, Therapeutic methods
Endotoxins metabolism
Female
Fibrinogen genetics
Fibrinogen metabolism
Gene Expression
Heart Rate drug effects
Heart Rate physiology
Humans
Hydroxyethyl Starch Derivatives administration & dosage
Male
Meningeal Neoplasms blood
Meningeal Neoplasms pathology
Meningeal Neoplasms surgery
Meningioma blood
Meningioma pathology
Meningioma surgery
Middle Aged
Osteocalcin genetics
Osteocalcin metabolism
Peptide Fragments genetics
Peptide Fragments metabolism
Plasma Substitutes administration & dosage
Polygeline administration & dosage
Procollagen genetics
Procollagen metabolism
Rhombencephalon drug effects
Rhombencephalon metabolism
Rhombencephalon pathology
Rhombencephalon surgery
Vascular Endothelial Growth Factor A genetics
Vascular Endothelial Growth Factor A metabolism
Blood Coagulation drug effects
Cardiotonic Agents therapeutic use
Drugs, Chinese Herbal therapeutic use
Hemodilution methods
Meningeal Neoplasms drug therapy
Meningioma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0393-974X
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of biological regulators and homeostatic agents
- Publication Type :
- Academic Journal
- Accession number :
- 29254304