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A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages.
- Source :
-
Cell host & microbe [Cell Host Microbe] 2017 Dec 13; Vol. 22 (6), pp. 733-745.e5. - Publication Year :
- 2017
-
Abstract
- Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tolerated by the host. In the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-driven inflammatory response in the intestine. Here we investigate the interactions between H. hepaticus and host immune cells that may promote mutualism, and the microbe-derived molecule(s) involved. Our results show that H. hepaticus triggers early IL-10 induction in intestinal macrophages and produces a large soluble polysaccharide that activates a specific MSK/CREB-dependent anti-inflammatory and repair gene signature via the receptor TLR2. These data identify a host-bacterial interaction that promotes mutualistic mechanisms at the intestinal interface. Further understanding of this pathway may provide novel prevention and treatment strategies for inflammatory bowel disease.<br /> (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Interleukin-10 metabolism
Interleukin-23 metabolism
Mice
Toll-Like Receptor 2 metabolism
Helicobacter hepaticus immunology
Helicobacter hepaticus metabolism
Immunosuppressive Agents metabolism
Macrophages drug effects
Macrophages immunology
Polysaccharides, Bacterial metabolism
Symbiosis
Subjects
Details
- Language :
- English
- ISSN :
- 1934-6069
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cell host & microbe
- Publication Type :
- Academic Journal
- Accession number :
- 29241040
- Full Text :
- https://doi.org/10.1016/j.chom.2017.11.002