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Evaluation of the effect of soft tissue composition on the characteristics of spread-out Bragg peak in proton therapy.
- Source :
-
Journal of cancer research and therapeutics [J Cancer Res Ther] 2017 Oct-Dec; Vol. 13 (6), pp. 974-980. - Publication Year :
- 2017
-
Abstract
- Aim: The aim of this study is to evaluate the effect of soft tissue composition on dose distribution and spread-out Bragg peak (SOBP) characteristics in proton therapy.<br />Subjects and Methods: Proton beams with nominal energies of 70, 120 and 210 MeV were considered. The soft tissues and tissue equivalent materials implemented in this study are: 9-component soft tissue, 4-component soft tissue, adipose tissue, muscle (skeletal), lung tissue, breast tissue, A-150 tissue equivalent plastic, perspex and water. Each material was separately defined inside a 20 cm × 20 cm × 40 cm phantom. A multilayer phantom was evaluated as well. The effect of tissue composition on the relative dose in SOBP region (relative to the dose in SOBP region in water), range of SOBP, length of SOBP, and uniformity index of SOBP was evaluated.<br />Results: Various soft tissues and tissue equivalent materials have shown different dose level in SOBPs, ranges of SOBPs, lengths of SOBPs and uniformity indices.<br />Conclusions: Based on the obtained results, various soft tissues and tissue equivalent materials have quite different SOBP characteristics. Since in clinical practice with proton therapy, only the range of SOBP is corrected for various tissues, omission of the above effects may result in major discrepancies in proton beam radiotherapy. To improve treatment accuracy, it is necessary to introduce such effects in treatment planning in proton therapy.
- Subjects :
- Adipose Tissue pathology
Adipose Tissue radiation effects
Breast pathology
Breast radiation effects
Humans
Lung pathology
Lung radiation effects
Monte Carlo Method
Muscle, Skeletal pathology
Muscle, Skeletal radiation effects
Phantoms, Imaging standards
Proton Therapy adverse effects
Soft Tissue Neoplasms pathology
Proton Therapy methods
Proton Therapy standards
Soft Tissue Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 1998-4138
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 29237962
- Full Text :
- https://doi.org/10.4103/0973-1482.220420