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Vaccine development targeting lipopolysaccharide structure modification.
- Source :
-
Microbes and infection [Microbes Infect] 2018 Oct - Nov; Vol. 20 (9-10), pp. 455-460. Date of Electronic Publication: 2017 Dec 09. - Publication Year :
- 2018
-
Abstract
- Vaccines are one of the most important methods for preventing infectious disease. Structural modification of lipopolysaccharide (LPS) provides a strategy for the development of live attenuated vaccines, either by altering the immunogenicity or by attenuating virulence of the bacteria. This review summarizes various approaches that utilize LPS mutants as whole-cell vaccines.<br /> (Copyright © 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Animals
Bacterial Vaccines genetics
Humans
Lipid A chemistry
Lipid A immunology
Lipopolysaccharides genetics
Mutation
O Antigens chemistry
O Antigens immunology
Oligosaccharides chemistry
Oligosaccharides immunology
Vaccines, Attenuated chemistry
Vaccines, Attenuated genetics
Vaccines, Attenuated immunology
Bacterial Vaccines chemistry
Bacterial Vaccines immunology
Gram-Negative Bacteria immunology
Lipopolysaccharides chemistry
Lipopolysaccharides immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1769-714X
- Volume :
- 20
- Issue :
- 9-10
- Database :
- MEDLINE
- Journal :
- Microbes and infection
- Publication Type :
- Academic Journal
- Accession number :
- 29233768
- Full Text :
- https://doi.org/10.1016/j.micinf.2017.11.006