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Volumetric analysis of keratocystic odontogenic tumors and non-neoplastic jaw cysts - Comparison and its clinical relevance.
- Source :
-
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery [J Craniomaxillofac Surg] 2018 Feb; Vol. 46 (2), pp. 257-263. Date of Electronic Publication: 2017 Nov 21. - Publication Year :
- 2018
-
Abstract
- The keratocystic odontogenic tumor (KCOT) is capable of causing vast osseous destruction. Histopathological examination is pivotal for diagnosis. The diagnostic process can sometimes be hindered by tissue inflammation of KCOTs with loss of defining criteria, resulting in misdiagnosis as an odontogenic jaw cyst. We discuss the possible merits of volumetric analysis when facing this particular diagnostic dilemma and for pathophysiological characterization of KCOTs. We included 114 patients, of whom 27 were histopathologically diagnosed with a KCOT and 87 with dentigerous (n = 41) and periapical cyst (n = 46). Semiautomatic segmentation and radiological analysis of preoperative cone beam computed tomography (CBCT) image data was carried out using ITK-SNAP. The mean volumetric extent of KCOTs is significantly higher compared to non-neoplastic odontogenic jaw cysts (p = 0.001). The mean volume and standard deviation for KCOTs and non-neoplastic odontogenic jaw cysts was 10381 mm <superscript>3</superscript>  ± 6410 and 5813 mm <superscript>3</superscript>  ± 4425, respectively. Volumetric analysis reveals that KCOTs significantly exceed the mean size of non-neoplastic odontogenic jaw cysts, adding an argument in favor of the neoplastic nature of KCOTs. In the case of difficult histopathological examination, lesions with a size exceeding a value of about 3000 mm <superscript>3</superscript> could be considered for close clinico-radiologic follow-up.<br /> (Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Child
Cone-Beam Computed Tomography
Dentigerous Cyst diagnosis
Dentigerous Cyst diagnostic imaging
Dentigerous Cyst pathology
Female
Humans
Jaw Cysts diagnosis
Jaw Cysts diagnostic imaging
Male
Middle Aged
Odontogenic Tumors diagnosis
Odontogenic Tumors diagnostic imaging
Radicular Cyst diagnosis
Radicular Cyst diagnostic imaging
Radicular Cyst pathology
Young Adult
Jaw Cysts pathology
Odontogenic Tumors pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-4119
- Volume :
- 46
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 29233700
- Full Text :
- https://doi.org/10.1016/j.jcms.2017.11.012