Safety of biologics in psoriasis.

Authors :: Kamata M
Tada Y
Source :: The Journal of dermatology [J Dermatol] 2018 Mar; Vol. 45 (3), pp. 279-286. Date of Electronic Publication: 2017 Dec 10.
Publication Year :: 2018
Abstract: The advent of biologics brought a paradigm shift in ways to treat psoriatic patients because they have dramatic efficacy. At the same time, safety concerns about biologics have been raised. In this paper, we focus on the safety profile of biologics for psoriasis. As of 2017, six biologics are available in Japan. Two tumor necrosis factor-α inhibitors; infliximab and adalimumab, one anti-interleukin (IL)-12/23p40 antibody; ustekinumab, and IL-17 inhibitors; secukinumab, ixekizumab and brodalumab. Secukinumab and ixekizumab are anti-IL-17A antibodies. Brodalumab is an anti-IL17RA antibody. In this review, we pick up topics which have drawn attention regarding the safety of biologics and discuss them with recent published work.<br /> (© 2017 Japanese Dermatological Association.)