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Mechanical Evaluation of Tracheal Grafts on Different Scales.
- Source :
-
Artificial organs [Artif Organs] 2018 May; Vol. 42 (5), pp. 476-483. Date of Electronic Publication: 2017 Dec 11. - Publication Year :
- 2018
-
Abstract
- Tissue engineered (or bioengineered) tracheas are alternative options under investigation when the resection with end-to-end anastomosis cannot be performed. One approach to develop bioengineered tracheas is a complex process that involves the use of decellularized tissue scaffolds, followed by recellularization in custom-made tracheal bioreactors. Tracheas withstand pressure variations and their biomechanics are of great importance so that they do not collapse during respiration, although there has been no preferred method of mechanical assay of tracheas among several laboratories over the years. These methods have been performed in segments or whole tracheas and in different species of mammals. This article aims to present some methods used by different research laboratories to evaluate the mechanics of tracheal grafts and presents the importance of the tracheal biomechanics in both macro and micro scales. If bioengineered tracheas become a reality in hospitals in the next few years, the standardization of biomechanical parameters will be necessary for greater consistency of results before transplantations.<br /> (© 2017 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.)
- Subjects :
- Animals
Bioengineering methods
Biomechanical Phenomena
Humans
Tissue Transplantation methods
Trachea chemistry
Trachea cytology
Trachea physiology
Transplants chemistry
Transplants cytology
Transplants physiology
Transplants transplantation
Bioartificial Organs
Tissue Engineering methods
Tissue Scaffolds chemistry
Trachea transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1525-1594
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Artificial organs
- Publication Type :
- Academic Journal
- Accession number :
- 29226358
- Full Text :
- https://doi.org/10.1111/aor.13063