Cohort-friendly protocol for a sensitive and fast method for trihalomethanes in urine using gas chromatography-Triple quadrupole mass spectrometry.

Authors :: Charisiadis P
Makris KC
Source :: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2018 Jan 01; Vol. 1072, pp. 336-340.
Publication Year :: 2018
Abstract: A cohort-friendly biomonitoring protocol has been developed for measuring biomarkers of exposure to disinfection by-products (trihalomethanes, THM) in urine using small initial volume (3mL) and short analysis time (∼10min) that facilitates the throughput of a large number of samples. The objective of this study was to optimise a cohort-friendly biomonitoring protocol for the determination of four THM analytes in human urine using gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ-MS/MS). The proposed methodology will facilitate the inclusion of such urinary THM measurements into large population health studies.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)

Subjects :: 1-Propanol
Acetone
Humans
Limit of Detection
Linear Models
Reproducibility of Results
Trihalomethanes chemistry
Trihalomethanes isolation & purification
Gas Chromatography-Mass Spectrometry methods
Tandem Mass Spectrometry methods
Trihalomethanes urine

Language :: English
ISSN :: 1873-376X
Volume :: 1072
Database :: MEDLINE
Journal :: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Publication Type :: Academic Journal
Accession number :: 29223046
Full Text :: https://doi.org/10.1016/j.jchromb.2017.11.045

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