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Four new compounds from the roots of Euphorbia ebracteolata and their inhibitory effect on LPS-induced NO production.
- Source :
-
Fitoterapia [Fitoterapia] 2018 Mar; Vol. 125, pp. 235-239. Date of Electronic Publication: 2017 Dec 05. - Publication Year :
- 2018
-
Abstract
- Three new diterpenoids, ebractenoids O~Q (1-3), and a new phenolic glucoside, γ-pyrone-3-O-β-d-(6-galloyl)-glucopyranoside (4), together with 6 known compounds, were isolated from the 95% ethanol extract of the roots of Euphorbia ebracteolata, and their structures were elucidated on the basis of spectroscopic data. The absolute configurations of 1-3 were determined by electronic circular dichroism (ECD) calculations. The inhibitory effects of all the isolates with exception of compounds 8 and 10 on the NO production in lipopolysaccharide (LPS)-induced macrophages were evaluated. All of them exhibited significant inhibitory activity.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Diterpenes isolation & purification
Glucosides isolation & purification
Lipopolysaccharides
Macrophages drug effects
Mice
Molecular Structure
Nitric Oxide metabolism
Phenols isolation & purification
Plant Roots chemistry
RAW 264.7 Cells
Diterpenes chemistry
Euphorbia chemistry
Glucosides chemistry
Phenols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 125
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 29221703
- Full Text :
- https://doi.org/10.1016/j.fitote.2017.12.006