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Hyperpolarization of amino acid derivatives in water for biological applications.
- Source :
-
Chemical science [Chem Sci] 2015 Jul 01; Vol. 6 (7), pp. 4261-4266. Date of Electronic Publication: 2015 May 26. - Publication Year :
- 2015
-
Abstract
- We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% <superscript>13</superscript> C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.
Details
- Language :
- English
- ISSN :
- 2041-6520
- Volume :
- 6
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Chemical science
- Publication Type :
- Academic Journal
- Accession number :
- 29218193
- Full Text :
- https://doi.org/10.1039/c5sc00503e