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Amniotic fluid oxidant-antioxidant status in foetal congenital nervous system anomalies.
- Source :
-
The Journal of international medical research [J Int Med Res] 2018 Mar; Vol. 46 (3), pp. 1146-1152. Date of Electronic Publication: 2017 Dec 06. - Publication Year :
- 2018
-
Abstract
- Objective This study aimed to evaluate the oxidant-antioxidant status of amniotic fluid in pregnant women with foetal congenital malformations of the central nervous system. Methods We studied pregnant women with foetal congenital nervous system anomalies at 16-22 weeks' gestation (n = 36). The control group (n = 30) consisted of pregnant women at the same gestational age who underwent amniocentesis, resulting in a normal karyotype. We analysed glutathione, catalase, and malondialdehyde levels in amniotic fluid. Enzyme activation was measured by spectrophotometry. Results The demographic features of the groups were similar in terms of age, parity, body mass index, and gestational weeks. We detected lower glutathione and catalase levels in the foetal congenital anomaly group than in the control group. We detected higher malondialdehyde levels in the foetal congenital anomaly group than in the control group. Conclusion In the organism, the rate of formation of free radicals and their rate of removal are balanced, and this is called oxidative balance. As long as oxidative stability is achieved, the organism is not affected by free radicals. This fact should be kept in mind to avoid any type of teratogenic agent that could lead to congenital disorders.
- Subjects :
- Adult
Amniocentesis
Biomarkers metabolism
Body Mass Index
Case-Control Studies
Female
Fetus
Gestational Age
Humans
Nervous System Malformations metabolism
Nervous System Malformations pathology
Parity
Pregnancy
Amniotic Fluid chemistry
Catalase metabolism
Glutathione metabolism
Malondialdehyde metabolism
Nervous System Malformations diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1473-2300
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of international medical research
- Publication Type :
- Academic Journal
- Accession number :
- 29210307
- Full Text :
- https://doi.org/10.1177/0300060517734443