A hemin auxotrophic Enterobacter cloacae clinical isolate with increased resistance to carbapenems and aminoglycosides.

Authors :: Tada T
Uechi K
Nakasone I
Miyazato Z
Shinzato T
Shimada K
Tsuchiya M
Kirikae T
Fujita J
Source :: Journal of medical microbiology [J Med Microbiol] 2018 Jan; Vol. 67 (1), pp. 29-32. Date of Electronic Publication: 2017 Dec 05.
Publication Year :: 2018
Abstract: Small-colony variants (SCVs) were obtained from an Enterobacter cloacae clinical isolate in Okinawa, Japan. One variant showed auxotrophy for hemin with a deletion of 20 365 nucleotides, dosC-ydiK-mmuP-mmuM-tauA-tauB-tauC-tauD-hemB-yaiT-yaiV-ampH-yddQ-sbmA-yaiW-yaiY-yaiZ, including hemB, and was more resistant to aminoglycosides and carbapenems, but more susceptible to aztreonam, than the parent strain.

Subjects :: Aztreonam pharmacology
Bacterial Proteins genetics
Enterobacter cloacae genetics
Hemin
Humans
Japan
Sequence Deletion genetics
Aminoglycosides pharmacology
Anti-Bacterial Agents pharmacology
Carbapenems pharmacology
Drug Resistance, Multiple, Bacterial drug effects
Enterobacter cloacae drug effects
Enterobacter cloacae isolation & purification

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