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Association Between Marginal Jawbone Loss and Onset of Rheumatoid Arthritis and Relationship to Plasma Levels of RANKL.
- Source :
-
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2018 Apr; Vol. 70 (4), pp. 508-515. Date of Electronic Publication: 2018 Mar 07. - Publication Year :
- 2018
-
Abstract
- Objective: To investigate whether periodontitis, characterized by marginal jawbone loss, precedes the onset of symptoms of rheumatoid arthritis (RA), and to analyze plasma levels of RANKL (a cytokine that is crucial for bone resorption) and anti-citrullinated peptide antibodies (ACPAs) in presymptomatic individuals compared with matched referent controls.<br />Methods: Marginal jawbone loss was measured on dental radiographs of the premolar/molar regions in the jaws in 176 subjects, 93 of whom subsequently developed RA. Among these participating subjects, 46 had documented radiographs predating symptom onset, and 45 cases could be matched to controls, according to sex, age, and smoking status. Plasma RANKL concentrations were analyzed using enzyme-linked immunosorbent assay. A receiver operating characteristic curve was used to define the cutoff value for RANKL positivity.<br />Results: Bone loss was significantly greater in presymptomatic subjects classified as never smokers compared with that in controls, and increasing levels of bone loss were associated with a higher risk of the subsequent development of RA (hazard ratio 1.03, 95% confidence interval 1.01-1.05). No association between jawbone loss and RA was observed in smokers. A significantly greater extent of marginal jawbone loss was detected in RANKL-positive presymptomatic subjects, and even more pronounced jawbone loss was observed in those who were positive for both RANKL and ACPA.<br />Conclusion: Marginal jawbone loss preceded the clinical onset of RA symptoms, but this was observed only in nonsmokers. Moreover, marginal jawbone loss was significantly greater in RANKL-positive presymptomatic subjects compared with RANKL-negative presymptomatic subjects and was highest in presymptomatic subjects positive for both ACPA and RANKL.<br /> (© 2017, American College of Rheumatology.)
- Subjects :
- Alveolar Bone Loss complications
Alveolar Bone Loss diagnostic imaging
Anti-Citrullinated Protein Antibodies blood
Case-Control Studies
Female
Humans
Jaw diagnostic imaging
Jaw Diseases complications
Jaw Diseases diagnostic imaging
Male
Middle Aged
Periodontitis complications
Periodontitis diagnostic imaging
Risk Factors
Alveolar Bone Loss blood
Arthritis, Rheumatoid etiology
Jaw Diseases blood
Periodontitis blood
RANK Ligand blood
Subjects
Details
- Language :
- English
- ISSN :
- 2326-5205
- Volume :
- 70
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Arthritis & rheumatology (Hoboken, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 29195021
- Full Text :
- https://doi.org/10.1002/art.40394