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Tonsillectomy and risk of Parkinson's disease: A danish nationwide population-based cohort study.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2018 Feb; Vol. 33 (2), pp. 321-324. Date of Electronic Publication: 2017 Nov 29. - Publication Year :
- 2018
-
Abstract
- Background: We hypothesized that tonsillectomy modifies the risk of PD.<br />Objectives: To test the hypothesis in a nationwide population-based cohort study.<br />Methods: We used Danish medical registries to construct a cohort of all patients in Denmark with an operation code of tonsillectomy 1980-2010 (n = 195,169) and a matched age and sex general population comparison cohort (n = 975,845). Patients were followed until PD diagnosis, death, censoring, or end of follow-up 30 November 2013. Using Cox regression, we computed hazard ratios for PD and corresponding 95% confidence intervals, adjusting for age and sex by study design, and potential confounders.<br />Results: We identified 100 and 568 patients diagnosed with PD among the tonsillectomy and general population comparison cohort, respectively, finding similar risks of PD (adjusted hazard ratio = 0.95 [95% confidence interval: 0.76-1.19]; for > 20 years' follow-up (adjusted hazard ratio = 0.96 [95% confidence interval: 0.64-1.41]).<br />Conclusion: Tonsillectomy is not associated with risk of PD, especially early-onset PD. © 2017 International Parkinson and Movement Disorder Society.<br /> (© 2017 International Parkinson and Movement Disorder Society.)
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 29193401
- Full Text :
- https://doi.org/10.1002/mds.27253