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H19 lncRNA regulates keratinocyte differentiation by targeting miR-130b-3p.
- Source :
-
Cell death & disease [Cell Death Dis] 2017 Nov 30; Vol. 8 (11), pp. e3174. Date of Electronic Publication: 2017 Nov 30. - Publication Year :
- 2017
-
Abstract
- Aberrant differentiation of keratinocytes has been demonstrated to be associated with a number of skin diseases. A growing number of studies have showed that long noncoding RNAs (lncRNAs) have an important part in gene regulation, however, the role of lncRNAs in keratinocyte differentiation remains to be largely unknown. In the present study, we demonstrated that lncRNA-H19 act as an endogenous 'sponge', which binds directly to miR-130b-3p and therefore inhibits its activity on Dsg1. MiR-130b-3p was illustrated to inhibit keratinocyte differentiation by targeting Dsg1. H19 regulates Dsg1 expression and the consequent keratinocyte differentiation through miR-130b-3p. Our study casts light on a novel regulatory model of keratinocyte differentiation, which may provide new therapeutic targets of skin diseases.
- Subjects :
- Cell Differentiation physiology
Child
Desmoglein 1 genetics
Desmoglein 1 metabolism
Gene Expression Regulation
Genes, Tumor Suppressor
Humans
Keratinocytes cytology
Keratinocytes metabolism
MicroRNAs antagonists & inhibitors
Transfection
Keratinocytes physiology
MicroRNAs genetics
MicroRNAs metabolism
RNA, Long Noncoding genetics
RNA, Long Noncoding metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-4889
- Volume :
- 8
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cell death & disease
- Publication Type :
- Academic Journal
- Accession number :
- 29192645
- Full Text :
- https://doi.org/10.1038/cddis.2017.516