Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression.

Authors :: Shibata H
Ohike N
Norose T
Isobe T
Suzuki R
Imai H
Shiokawa A
Aoki T
Murakami M
Mizukami H
Tanaka JI
Takimoto M
Source :: Anticancer research [Anticancer Res] 2017 Dec; Vol. 37 (12), pp. 7063-7068.
Publication Year :: 2017
Abstract: Background: Pancreatic and hepatic mucinous cyst neoplasms (MCNs) have a malignant potential, but indolent MCNs are not uncommon.<br />Materials and Methods: The pathological and genetic characteristics of resected MCNs (n=15) categorized by the amount of mucin of the lining epithelium were investigated.<br />Results: MCNs were divided into two groups: (i) a rich (r)-MCN group (n=6), in which more than half of the epithelium was lined by abundant mucinous epithelium; and (ii) a poor (p)-MCN group (n=9), which consisted of the remaining cases. Three patients in the r-MCN group showed invasive carcinoma or high-grade dysplasia, whereas all patients in the p-MCN group showed low-grade dysplasia. Mutations of Kirsten rat sarcoma viral oncogene homolog (KRAS) were more frequent in the r-MCN group (83%) (p-MCN; 11%, p<0.05).<br />Conclusion: Mucinous MCNs more frequently have KRAS mutations and higher risk of malignant progression.<br /> (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

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