EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials.

At a meeting of the EU/US/Clinical Trials in Alzheimer's Disease (CTAD) Task Force in December 2016, an international group of investigators from industry, academia, and regulatory agencies reviewed lessons learned from ongoing and planned prevention trials, which will help guide future clinical trials of AD treatments, particularly in the pre-clinical space. The Task Force discussed challenges that need to be addressed across all aspects of clinical trials, calling for innovation in recruitment and retention, infrastructure development, and the selection of outcome measures. While cognitive change provides a marker of disease progression across the disease continuum, there remains a need to identify the optimal assessment tools that provide clinically meaningful endpoints. Patient- and informant-reported assessments of cognition and function may be useful but present additional challenges. Imaging and other biomarkers are also essential to maximize the efficiency of and the information learned from clinical trials.
Competing Interests: P. Aisen: NeuroPhage, Eli Lilly, Merck, Roche, Amgen, Abbvie, Pfizer, Novartis, Janssen, Lundbeck, Biogen, iPerian, Probiodrug, Anavex, Cohbar, Cytox, aTyr, Avanir; R. Bateman: Abbvie, AstraZeneca, Biogen, Eisai, Eli Lilly and Co., Hoffman La-Roche Inc., Janssen, Pfizer, Sanofi-Aventi; N. Fox: Janssen, Roche, Eli Lilly, Novartis, GSK, Biogen; S. Gauthier: Eli Lilly, TauRx, Roche, Eisai, Lundbeck, Schwabe; L. Schneider: Eli Lilly, Novartis, Roche/Genentech, Takeda; P. Tariot: Roche, Novartis, Amgen, Abbvie, Eli Lilly, AstraZeneca, Lundbeck, AC Immune, Merck, Takeda, Boehringer-Ingelheim; K. Welsh-Bohmer: Takeda, Merck, Biogen, Roche, J and J; B. Vellas: Biogen, Eli Lilly, Roche, Nestlé, Merck; R. Sperling: Avid/Lilly, Janssen, Bracket, Genetech, Sanofi, Roche, Abbvie, Lundbeck, Otsuka, Merck. S. Henrix: Pentara Corporation; R. Doody: Genentech/Roche; C. Ho, J. Breitner, R. Amariglio, M. Grundman, R. Raman, M. Isaac: No conflict of interest. The Task Force was partially funded by registration fees from industrial participants. These corporations placed no restrictions on this work.