Palladium-Catalyzed Dearomative syn-1,4-Carboamination.

Authors :: Okumura M
Shved AS
Sarlah D
Source :: Journal of the American Chemical Society [J Am Chem Soc] 2017 Dec 13; Vol. 139 (49), pp. 17787-17790. Date of Electronic Publication: 2017 Dec 05.
Publication Year :: 2017
Abstract: A dearomative 1,4-carboamination of arenes has been achieved using arenophile cycloaddition and subsequent palladium-catalyzed substitution with nonstabilized lithium enolates. This protocol delivers products with exclusive syn-1,4-selectivity and can be also conducted in an asymmetric fashion. The method allows rapid dearomative difunctionalization of simple aromatic compounds into functional small molecules amenable to further diversification.