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Molecular pathology of total knee arthroplasty instability defined by RNA-seq.
- Source :
-
Genomics [Genomics] 2018 Sep; Vol. 110 (5), pp. 247-256. Date of Electronic Publication: 2017 Nov 22. - Publication Year :
- 2018
-
Abstract
- Total knee arthroplasty (TKA) is a durable and reliable procedure to alleviate pain and improve joint function. However, failures related to flexion instability sometimes occur. The goal of this study was to define biological differences between tissues from patients with and without flexion instability of the knee after TKA. Human knee joint capsule tissues were collected at the time of primary or revision TKAs and analyzed by RT-qPCR and RNA-seq, revealing novel patterns of differential gene expression between the two groups. Interestingly, genes related to collagen production and extracellular matrix (ECM) degradation were higher in samples from patients with flexion instability. Partitioned clustering analyses further emphasized differential gene expression patterns between sample types that may help guide clinical interpretations of this complication. Future efforts to disentangle the effects of physical and biological (e.g., transcriptomic modifications) risk factors will aid in further characterizing and avoiding flexion instability after TKA.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Case-Control Studies
Extracellular Matrix genetics
Extracellular Matrix metabolism
Female
Humans
Joint Instability etiology
Joint Instability metabolism
Knee Joint metabolism
Knee Joint pathology
Knee Joint surgery
Male
Middle Aged
Oxidative Stress
Postoperative Complications metabolism
Arthroplasty, Replacement, Knee adverse effects
Joint Instability genetics
Postoperative Complications genetics
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 1089-8646
- Volume :
- 110
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 29174847
- Full Text :
- https://doi.org/10.1016/j.ygeno.2017.11.001