Back to Search
Start Over
TGF-β1/Smad2/3/Foxp3 signaling is required for chronic stress-induced immune suppression.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2018 Jan 15; Vol. 314, pp. 30-41. Date of Electronic Publication: 2017 Nov 08. - Publication Year :
- 2018
-
Abstract
- Depending on the duration and severity, psychological tension and physical stress can enhance or suppress the immune system in both humans and animals. Although it has been established that chronic stress exerts a significant suppressive effect on immune function, the mechanisms by which affects immune responses remain elusive. By employing an in vivo murine system, we revealed that TGF-β1/Smad2/3/Foxp3 axis was remarkably activated following chronic stress. Furthermore, TLR9 and p38 MAPK played a critical role in the activation of TGF-β1/Smad2/3/Foxp3 signaling cascade. Moreover, inhibition of TGF-β1/Smad2/3/Foxp3 or p38 significantly attenuated chronic stress-induced lymphocyte apoptosis and apoptosis-related proteins, as well as the differentiation of T regulatory cells in spleen. Interestingly, disequilibrium of pro-inflammatory and anti-inflammatory cytokines balance caused by chronic stress was also rescued by blocking TGF-β1/Smad2/3/Foxp3 axis. These findings yield insight into a novel mechanism by which chronic stress modulates immune functions and identifies new targets for the development of novel anti-immune suppressant medications.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Forkhead Transcription Factors immunology
Forkhead Transcription Factors metabolism
Male
Mice
Mice, Inbred BALB C
Smad2 Protein immunology
Smad2 Protein metabolism
Smad3 Protein immunology
Smad3 Protein metabolism
Stress, Psychological metabolism
Transforming Growth Factor beta1 immunology
Transforming Growth Factor beta1 metabolism
Immune Tolerance immunology
Signal Transduction immunology
Stress, Psychological immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 314
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 29169800
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2017.11.005