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Perioperative Antibiotic Prophylaxis Has No Effect on Time to Positivity and Proportion of Positive Samples: a Cohort Study of 64 Cutibacterium acnes Bone and Joint Infections.
- Source :
-
Journal of clinical microbiology [J Clin Microbiol] 2018 Jan 24; Vol. 56 (2). Date of Electronic Publication: 2018 Jan 24 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- If a bone or joint infection is suspected, perioperative antibiotic prophylaxis is frequently withheld until intraoperative microbiological sampling has been performed. This practice builds upon the hypothesis that perioperative antibiotics could render culture results negative and thus impede tailored antibiotic treatment of infections. We aimed to assess the influence of antibiotic prophylaxis within 30 to 60 min before surgery on time to positivity of microbiological samples and on proportion of positive samples in Cutibacterium acnes bone and joint infections. Patients with at least one sample positive for C. acnes between January 2005 and December 2015 were included and classified as having an "infection" if at least 2 samples were positive; otherwise they were considered to have a sample "contamination." Kaplan-Meier curves were used to illustrate time to culture positivity. We found 64 cases with a C. acnes infection and 46 classified as having a C. acnes contamination. Application of perioperative prophylaxis significantly differed between the infection and contamination groups (72.8% versus 55.8%; P < 0.001). Within the infection group, we found no difference in time to positivity between those who had or had not received a perioperative prophylaxis (7.07 days; 95% confidence interval [CI], 6.4 to 7.7, versus 7.11 days; 95% CI, 6.8 to 7.5; P = 0.3). Also, there was no association between the proportion of sample positivity and the application of perioperative prophylaxis (71.6% versus 65.9%; P = 0.39). Since perioperative prophylaxis did not negatively influence the microbiological yield in C. acnes infections, antibiotic prophylaxis can be routinely given to avoid surgical site infections.<br /> (Copyright © 2018 American Society for Microbiology.)
- Subjects :
- Aged
Antibiotic Prophylaxis statistics & numerical data
Arthritis, Infectious drug therapy
Arthritis, Infectious prevention & control
Cohort Studies
Female
Humans
Male
Middle Aged
Orthopedic Procedures
Osteomyelitis drug therapy
Osteomyelitis microbiology
Osteomyelitis prevention & control
Perioperative Care
Surgical Wound Infection prevention & control
Anti-Bacterial Agents administration & dosage
Antibiotic Prophylaxis standards
Arthritis, Infectious diagnosis
Osteomyelitis diagnosis
Propionibacteriaceae isolation & purification
Surgical Wound Infection diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1098-660X
- Volume :
- 56
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of clinical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 29167293
- Full Text :
- https://doi.org/10.1128/JCM.01576-17