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Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort.
- Source :
-
International journal of cancer [Int J Cancer] 2018 Apr 01; Vol. 142 (7), pp. 1355-1360. Date of Electronic Publication: 2017 Dec 11. - Publication Year :
- 2018
-
Abstract
- CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases. We investigated these objectives using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to four matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2-year lag-time intervals were calculated using conditional logistic regression calibrated toward the absolute risk estimates from a pre-existing epidemiological risk model as an offset-variable. Anti-CA125 levels alone did not discriminate cases from controls. For cases diagnosed <2 years after blood collection, discrimination by CA125 antigen was suggestively higher with higher anti-CA125 levels (aAUC, highest antibody tertile: 0.84 [0.76-0.92]; lowest tertile: 0.76 [0.67-0.86]; p <subscript>het</subscript> = 0.06). We provide the first evidence of potentially synergistic discrimination effects of CA125 and anti-CA125 antibodies in ovarian early detection. If these findings are replicated, evaluating CA125 in the context of its antibody may improve ovarian cancer early detection.<br /> (© 2017 UICC.)
- Subjects :
- Adult
Aged
Area Under Curve
Biomarkers, Tumor immunology
CA-125 Antigen blood
Case-Control Studies
Cohort Studies
Female
Humans
Membrane Proteins blood
Middle Aged
ROC Curve
Sensitivity and Specificity
Autoantibodies blood
Biomarkers, Tumor blood
CA-125 Antigen immunology
Early Detection of Cancer methods
Membrane Proteins immunology
Ovarian Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0215
- Volume :
- 142
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 29159934
- Full Text :
- https://doi.org/10.1002/ijc.31164