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Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.
- Source :
-
Scientific reports [Sci Rep] 2017 Nov 20; Vol. 7 (1), pp. 15843. Date of Electronic Publication: 2017 Nov 20. - Publication Year :
- 2017
-
Abstract
- Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.
- Subjects :
- Europe
Female
Genome-Wide Association Study
Genotype
Hepacivirus genetics
Hepacivirus pathogenicity
Hepatitis C pathology
Hepatitis C virology
Humans
Interferons
Male
North America
Polymorphism, Single Nucleotide genetics
Genetic Predisposition to Disease
Hepatitis C genetics
Interleukins genetics
Major Histocompatibility Complex genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29158528
- Full Text :
- https://doi.org/10.1038/s41598-017-16011-2