Gold nanoparticles potentiate Ca V channel currents in rat tail artery myocytes.

Authors :: Fusi F
Sgaragli G
Valoti M
Source :: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2018 Mar; Vol. 47, pp. 89-93. Date of Electronic Publication: 2017 Nov 20.
Publication Year :: 2018
Abstract: This study was designed to unveil effects of 5-nm sized, polyvinylpyrrolidone-coated gold nanoparticles (AuNPs) on vascular Ca <subscript>V</subscript> 1.2 and Ca <subscript>V</subscript> 3.1 channels. Ba <superscript>2+</superscript> currents through both channels (I <subscript>Ba1.2</subscript> and I <subscript>Ba3.1</subscript> ) were recorded in single myocytes isolated from the rat tail main artery by means of the whole-cell patch-clamp method. AuNPs increased I <subscript>Ba1.2</subscript> and I <subscript>Ba3.1</subscript> amplitude in a concentration- and V <subscript>h</subscript> -dependent manner. Neither the voltage dependence of inactivation and activation curves nor inactivation and activation kinetics were affected by AuNPs. In conclusion, these findings warrant further investigation to clarify whether different types of NPs possess the same stimulatory activity and may represent a toxic hazard to humans.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Language :: English
ISSN :: 1879-3177
Volume :: 47
Database :: MEDLINE
Journal :: Toxicology in vitro : an international journal published in association with BIBRA
Publication Type :: Academic Journal
Accession number :: 29158021
Full Text :: https://doi.org/10.1016/j.tiv.2017.11.013

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