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Polyphosphonate ligands: From synthesis to design of hybrid PEGylated nanoparticles toward phototherapy studies.
- Source :
-
Journal of colloid and interface science [J Colloid Interface Sci] 2018 Mar 01; Vol. 513, pp. 205-213. Date of Electronic Publication: 2017 Nov 02. - Publication Year :
- 2018
-
Abstract
- The use of phosphonate ligands to modify the nanoparticle (NPs) surface has attracted a strong interest in the last years for the design of highly functional hybrid materials. Here, we applied a methodology to synthesize bisphosphonates having functionalized PEG side chains with a specific length in order to design a novel class of hybrid nanomaterials composed by tetraphosphonate-complex-gold COOH-terminated PEG-coated NPs (Bis-PO-PEG-AuNPs). The synthetic approach consist in three steps: (1) Complexation between new phosphonate ligands (Bis PO) and tetrachloroauric acid (HAuCl <subscript>4</subscript> ) to form gold clusters; (2) adsorption of COOH-terminated PEG molecules (PEG) onto Bis PO-Au complex; (3) reduction of metal ions in that vicinity, growth of gold particles and colloidal stabilization. The obtained snow-shape-like hybrid nanoparticles, have been characterized by ultra-violet/visible, Raman spectroscopies, and electron microscopy imaging, involving their optical properties and photothermal activity in pancreatic adenocarcinoma cancer cells (PDAC).<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Gold chemistry
Humans
Ligands
Metal Nanoparticles chemistry
Organophosphorus Compounds chemistry
Tumor Cells, Cultured
Carcinoma, Pancreatic Ductal therapy
Metal Nanoparticles administration & dosage
Organophosphorus Compounds administration & dosage
Pancreatic Neoplasms therapy
Phototherapy
Polyethylene Glycols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1095-7103
- Volume :
- 513
- Database :
- MEDLINE
- Journal :
- Journal of colloid and interface science
- Publication Type :
- Academic Journal
- Accession number :
- 29153714
- Full Text :
- https://doi.org/10.1016/j.jcis.2017.10.055