Understanding the pathogenesis of vascular calcification: timing is everything.

A number of histologic changes are associated with the medial arterial calcification that occurs in chronic kidney disease, leading to several different hypotheses concerning the underlying mechanism. Careful timing of these changes in relation to the onset of the calcification, as reported in this issue of the journal, can shed light on which changes are pathogenic as opposed to secondary in reaction to the calcification.
(Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)