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Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2018 Mar 15; Vol. 57 (6), pp. 855-860. Date of Electronic Publication: 2017 Nov 20. - Publication Year :
- 2018
-
Abstract
- Solitary bone plasmacytoma (SBP) tends to progress to multiple myeloma (MM); however, progression to multiple solitary plasmacytomas (MSP) is rare. We report a case of CD138-low MSP with 17p deletion in a patient with relapsed SBP. 17p deletion is associated with a poor outcome in patients with MM, and the low expression of CD138 in myeloma cells is associated with drug resistance and a poor prognosis. The patient was successfully treated with bortezomib plus dexamethasone induction therapy and autologous hematopoietic stem cell transplantation followed by bortezomib maintenance therapy. Consequently, bortezomib treatment was stopped and a stringent complete response has been maintained.
- Subjects :
- Chromosome Deletion
Humans
Male
Middle Aged
Neoplasm Recurrence, Local genetics
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bortezomib therapeutic use
Hematopoietic Stem Cell Transplantation methods
Multiple Myeloma genetics
Multiple Myeloma therapy
Neoplasm Recurrence, Local therapy
Transplantation, Autologous methods
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 57
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 29151530
- Full Text :
- https://doi.org/10.2169/internalmedicine.9446-17