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Sensitization to Staphylococcus aureus enterotoxins in smokers with asthma.
- Source :
-
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2017 Nov; Vol. 119 (5), pp. 408-414.e2. - Publication Year :
- 2017
-
Abstract
- Background: Sensitization to Staphylococcus aureus enterotoxins (SEs) augments eosinophilic inflammation in asthma. Recent epidemiologic studies demonstrate that sensitization to SEs is increased in healthy smokers; however, there is no evidence on the association between sensitization to SEs and eosinophilic inflammation in smokers with asthma.<br />Objective: To clarify the role of SEs on clinical indexes, including eosinophilic inflammation and lung function in smokers with asthma.<br />Methods: The frequency of atopic sensitization to SEs was examined in adult patients with asthma. In current or ex-smokers with asthma, the association of sensitization to SEs with eosinophilic inflammation, airflow limitation, or treatment steps was determined. Clinical indexes were examined at the first visit, and treatment steps were assessed 6 months after enrollment.<br />Results: Overall, 23 current smokers, 40 ex-smokers, and 118 never smokers with asthma were enrolled. The frequency of sensitization to SEs, but not to other aeroallergens, was significantly higher in current, ex-, and never smokers, in decreasing order. In current or ex-smokers with asthma, patients with sensitization to SEs exhibited higher serum levels of total and specific IgE to aeroallergens, higher blood eosinophil counts, greater airflow limitation, and more severe disease 6 months later than those without sensitization to SE. A longer smoking abstinence period was associated with serum specific IgE levels to SEs, and 3 years was the best cutoff of abstinence period to predict the absence of sensitization to SEs.<br />Conclusion: Sensitization to SEs is increased in smokers with asthma, and it may be a marker of eosinophilic inflammation and severe asthma in smokers with asthma.<br />Trial Registration: umin.ac.jp Identifier: UMIN000007818.<br /> (Copyright © 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Air Pollution adverse effects
Allergens immunology
Asthma epidemiology
Cigarette Smoking epidemiology
Female
Follow-Up Studies
Humans
Immunization
Male
Middle Aged
Prevalence
Respiratory Function Tests
Staphylococcal Infections epidemiology
United States epidemiology
Young Adult
Asthma immunology
Enterotoxins immunology
Eosinophils immunology
Staphylococcal Infections immunology
Staphylococcus aureus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1534-4436
- Volume :
- 119
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29150068
- Full Text :
- https://doi.org/10.1016/j.anai.2017.08.001