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Genetic risk factors for perception of symptoms in GERD: an observational cohort study.
- Source :
-
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2018 Jan; Vol. 47 (2), pp. 289-297. Date of Electronic Publication: 2017 Nov 17. - Publication Year :
- 2018
-
Abstract
- Background: Genetic polymorphisms in G-protein beta-3 subunit (GNβ3) and beta-2 adrenergic receptor (ADRB2) are associated with pain and gut hypersensitivity, which can overlap with gastroesophageal reflux disease (GERD).<br />Aim: To evaluate relationships between single nucleotide polymorphisms (SNPs) within GNβ3 and ADRB2 systems, and reflux symptom burden, GERD phenotypes from ambulatory reflux monitoring, and quality of life.<br />Methods: Symptomatic adults undergoing ambulatory reflux testing were recruited and phenotyped based on acid burden and symptom reflux association; major oesophageal motor disorders and prior foregut surgery were exclusions. A comparison asymptomatic control cohort was also identified. Subjects and controls completed questionnaires assessing symptom burden on visual analog scales, short-form health survey-36 (SF-36), and Beck Anxiety and Depression Inventories (BAI and BDI). Genotyping was performed from saliva samples; 6 SNPs selected from each of the two genes of interest were compared.<br />Results: Saliva from 151 study subjects (55.3 ± 1.2 years, 63.6% F) and 60 control subjects (50.9 ± 2.2 years, 66.7%) had sufficient genetic material for genotyping. Study subjects had higher symptom burden, worse total and physical health, and higher anxiety scores compared to controls (P ≤ .002). Tested SNPs within ADRB2 were similar between study subjects and controls (P > .09). Study subjects with recessive alleles in 3 GNβ3 SNPs (Rs2301339, Rs5443, and Rs5446) had worse symptom severity (P = .011), worse mental health (P = .03), and higher depression scores (P = .005) despite no associations with GERD phenotypes or reflux metrics.<br />Conclusions: Genetic variation within GNβ3 predicts oesophageal symptom burden and affect, but not oesophageal acid burden or symptom association with reflux episodes.<br /> (© 2017 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Case-Control Studies
Cohort Studies
Cost of Illness
Female
Food Hypersensitivity complications
Food Hypersensitivity epidemiology
Gastroesophageal Reflux complications
Gastroesophageal Reflux epidemiology
Genotype
Heterotrimeric GTP-Binding Proteins genetics
Humans
Male
Middle Aged
Pain epidemiology
Pain etiology
Pain Measurement
Pilot Projects
Polymorphism, Single Nucleotide
Receptors, Adrenergic, beta-2 genetics
Risk Factors
Surveys and Questionnaires
Food Hypersensitivity genetics
Gastroesophageal Reflux diagnosis
Gastroesophageal Reflux genetics
Genetic Predisposition to Disease
Pain genetics
Pain Perception
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2036
- Volume :
- 47
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Alimentary pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 29148080
- Full Text :
- https://doi.org/10.1111/apt.14414