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Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine.
- Source :
-
Macromolecular bioscience [Macromol Biosci] 2017 Dec; Vol. 17 (12). Date of Electronic Publication: 2017 Nov 16. - Publication Year :
- 2017
-
Abstract
- Pseudouridine (Ψ) is an important urinary cancer biomarker, especially in human colorectal cancer (CRC). Disclosed herein is the first Ψ molecularly imprinted polymer (Ψ-MIP) material obtained from tailor-engineered functional monomers. The resulting MIP imprint exhibits a remarkable imprinting factor greater than 70. It is successfully used for the selective recognition of Ψ in spiked human urine. This selective functionalized material opens the route to the development of inexpensive disposable chemosensors for noninvasive CRC diagnosis and prognosis.<br /> (© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Humans
Magnetic Resonance Spectroscopy
Molecular Imprinting methods
Polymerization
Polymers chemistry
Solid Phase Extraction instrumentation
Solid Phase Extraction methods
Solvents chemistry
Biomarkers, Tumor urine
Chromatography, High Pressure Liquid methods
Polymers chemical synthesis
Pseudouridine urine
Subjects
Details
- Language :
- English
- ISSN :
- 1616-5195
- Volume :
- 17
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Macromolecular bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 29144579
- Full Text :
- https://doi.org/10.1002/mabi.201700250