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Chronic Prurigo of Nodular Type: A Review.
- Source :
-
Acta dermato-venereologica [Acta Derm Venereol] 2018 Feb 07; Vol. 98 (2), pp. 173-179. - Publication Year :
- 2018
-
Abstract
- Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules. PN evolves along with chronic pruritus in the context of diverse dermatological, systemic, neurological or psychiatric conditions. Permanent scratching is possibly a major trigger of PN, although its exact pathophysiology remains unclear. Current state-of-the-art therapy for PN consists of topical steroids, capsaicin, calcineurin inhibitors, ultraviolet (UV) therapy, systemic administration of gabapentinoids, μ-opioid receptor antagonists, antidepressants or immunosuppressants. Novel treatment concepts, such as inhibitors of neurokinin-1, opioid and interleukin-31 receptors, have been developed and are currently being clinically tested.
- Subjects :
- Aged
Animals
Antidepressive Agents adverse effects
Chronic Disease
Dermatologic Agents adverse effects
Female
Humans
Immunosuppressive Agents adverse effects
Male
Middle Aged
Narcotic Antagonists adverse effects
Prurigo diagnosis
Prurigo epidemiology
Prurigo physiopathology
Pruritus diagnosis
Pruritus epidemiology
Pruritus physiopathology
Risk Factors
Treatment Outcome
Antidepressive Agents therapeutic use
Dermatologic Agents therapeutic use
Immunosuppressive Agents therapeutic use
Narcotic Antagonists therapeutic use
Prurigo therapy
Pruritus therapy
Ultraviolet Therapy adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2057
- Volume :
- 98
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta dermato-venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 29135018
- Full Text :
- https://doi.org/10.2340/00015555-2774