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Zonulin, inflammation and iron status in patients with early stages of chronic kidney disease.
- Source :
-
International urology and nephrology [Int Urol Nephrol] 2018 Jan; Vol. 50 (1), pp. 121-125. Date of Electronic Publication: 2017 Nov 13. - Publication Year :
- 2018
-
Abstract
- Background/aims: Zonulin is the only known regulator of intestinal permeability. It is also considered as a potential inflammatory marker in several conditions such as diabetes and inflammatory bowel syndrome. The aim of the study was to investigate zonulin levels in patients with early stages of CKD and its possible correlation with inflammation, anemia and iron status parameters.<br />Methods: Eighty-eight patients with early stages of CKD and 23 healthy volunteers were enrolled in the study. Zonulin, hepcidin-25, soluble transferrin receptor, interleukin-6 and high-sensitivity C-reactive protein were measured using commercially available assays.<br />Results: Zonulin was significantly lower among patients with CKD in comparison with healthy volunteers. There were no statistically significant differences in zonulin concentration between patients with and without inflammation. Zonulin was significantly correlated with hepcidin only in patients with inflammation. Zonulin was neither related to iron nor related to ferritin.<br />Conclusions: Zonulin cannot be considered as an inflammatory marker in CKD. It does not play a role in the disturbances of iron metabolism in CKD. Its physiological role remains to be elucidated.
- Subjects :
- Adult
Aged
Aged, 80 and over
Anemia blood
Anemia complications
Biomarkers blood
C-Reactive Protein metabolism
Case-Control Studies
Haptoglobins
Hepcidins blood
Humans
Inflammation complications
Interleukin-6 blood
Iron blood
Middle Aged
Protein Precursors
Receptors, Transferrin blood
Renal Insufficiency, Chronic complications
Cholera Toxin blood
Inflammation blood
Renal Insufficiency, Chronic blood
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2584
- Volume :
- 50
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International urology and nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 29134616
- Full Text :
- https://doi.org/10.1007/s11255-017-1741-5